| 2021-08-19 19:00:00August 19, 2021 | Oak Ridge | 20 - 28 |  South-Doyle | 19:00:007:00 pm | |
| 2021-08-19 19:00:00August 19, 2021 | Gatlinburg-Pittman  | 13 - 14 |  Seymour | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Carter  | 26 - 21 |  Knoxville Webb | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Cherokee | 41 - 6 |  Cocke County | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | CAK  | 33 - 6 |  TKA | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Hampton | 20 - 14 |  Pigeon Forge | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Heritage  | 0 - 49 |  Maryville | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Jefferson County  | 13 - 21 |  Sevier County | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Northview Academy  | 15 - 22 | Unicoi County | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | Sunbright | 53 - 24 |  Cosby | 19:00:007:00 pm | |
| 2021-08-20 19:00:00August 20, 2021 | William Blount  | 23 - 41 | Clinton | 19:00:007:00 pm | |
| 2021-08-20 19:00:44August 20, 2021 | Alcoa  | 41 - 13 | Rhea County | 19:00:447:00 pm | |
| 2021-08-26 19:00:00August 26, 2021 | Maryville | 52 - 31 | Powell | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | Alcoa | 56 - 7 | Gatlinburg-Pittman | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | Campbell County | 42 - 7 | Heritage | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | Cocke County | 0 - 60 | Jefferson County | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | Karns | 40 - 7 | William Blount | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | TKA | W - - | Meigs County | 19:00:00Canceled | |
| 2021-08-27 19:00:00August 27, 2021 | Pigeon Forge | 48 - 12 | Sullivan East | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | Seymour | 37 - 14 | Cherokee | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | South-Doyle | 34 - 27 | Grace Christian | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | Unicoi County | 44 - 0 | Cosby | 19:00:007:00 pm | |
| 2021-08-27 19:00:00August 27, 2021 | West Greene | - - W | Northview Academy | 19:00:00Canceled | |
| 2021-08-28 19:00:00August 28, 2021 | Sevier County | 35 - 42 | Carter | 19:00:007:00 pm | |
| 2021-09-02 19:00:00September 2, 2021 | Northview Academy | 8 - 63 | Alcoa | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Austin-East  | 27 - 44 | Gatlinburg-Pittman | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Cocke County | 29 - 27 | Heritage | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Cosby | 26 - 34 | Jellico | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Farragut | 14 - 42 | Maryville | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Gibbs | 35 - 42 | Carter | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Jefferson County | 17 - 14 | William Blount | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Knoxville Central | 35 - 13 | Sevier County | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Scott  | 10 - 42 | South-Doyle | 19:00:007:00 pm | |
| 2021-09-03 19:00:00September 3, 2021 | Union County  | - - W | Pigeon Forge | 19:00:00Canceled | |
| 2021-09-03 19:00:00September 3, 2021 | Volunteer | 28 - 14 | Seymour | 19:00:007:00 pm | |
| 2021-09-03 19:30:00September 3, 2021 | Heritage (Ringgold, GA) | 34 - 14 | TKA | 19:30:007:30 pm | |
| 2021-09-09 19:00:00September 9, 2021 | Loudon | 43 - 22 | Gatlinburg-Pittman | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Alcoa | 27 - 30 | Maryville | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Bearden | 7 - 26 | South-Doyle | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Carter | 14 - 42 | Walker Valley | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Claiborne | 0 - 35 | Northview Academy | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Cocke County | 7 - 49 | Seymour | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Heritage | 19 - 38 | William Blount | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | TKA | 22 - 20 | Grace Christian | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Knoxville Halls | 34 - 33 | Jefferson County | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Red Boiling Springs | 20 - 0 | Cosby | 19:00:007:00 pm | |
| 2021-09-10 19:00:00September 10, 2021 | Sevier County | 14 - 0 | Pigeon Forge | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Austin-East | 42 - 8 | Northview Academy | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Bearden | 6 - 42 | Maryville | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Carter | W - - | Scott | 19:00:00Canceled | |
| 2021-09-17 19:00:00September 17, 2021 | Friendship Christian | 21 - 28 | TKA | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Gatlinburg-Pittman | 49 - 6 | Union County | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Heritage | 0 - 51 | Knoxville Central | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Jefferson County | 28 - 12 |  Morristown East | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Knoxville Halls | 63 - 6 | Cocke County | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Pigeon Forge | - - W | Alcoa | 19:00:00Canceled | |
| 2021-09-17 19:00:00September 17, 2021 | Science Hill | 55 - 27 | William Blount | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | Seymour | 42 - 7 | Sullivan East | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | South-Doyle | 28 - 31 | Anderson County | 19:00:007:00 pm | |
| 2021-09-17 19:00:00September 17, 2021 | West  | 20 - 19 | Sevier County | 19:00:007:00 pm | |
| 2021-09-17 19:30:00September 17, 2021 | Coalfield | 30 - 34 | Carter | 19:30:007:30 pm | |
| 2021-09-23 19:00:00September 23, 2021 | West | 20 - 21 | Alcoa | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | TKA | W - - | Swain County (NC) | 19:00:00Canceled | |
| 2021-09-24 19:00:00September 24, 2021 | Cloudland | 52 - 18 | Cosby | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Cocke County | 0 - 41 |  Morristown West | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Gatlinburg-Pittman | 56 - 7 | Coosa Christian (AL) | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Karns | 48 - 25 | Carter | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Maryville | 41 - 17 | Science Hill | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Northview Academy | 0 - 19 | Oneida | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Pigeon Forge | 36 - 6 | Scott | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | Seymour | 27 - 12 | Heritage | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | South-Doyle | 21 - 28 | Farragut | 19:00:007:00 pm | |
| 2021-09-24 19:00:00September 24, 2021 | William Blount | 21 - 28 | Sevier County | 19:00:007:00 pm | |
| 2021-09-30 19:00:00September 30, 2021 | Anderson County | 48 - 14 | Carter | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Alcoa | 38 - 0 | Cookeville | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Dobyns-Bennett | 21 - 35 | Jefferson County | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Fulton | 21 - 43 | South-Doyle | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Heritage | 6 - 56 | West | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | TKA | 20 - 35 | Middle Tennessee Christian | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Knoxville Central | 69 - 0 | Cocke County | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Maryville | 42 - 7 | Cleveland | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | North Greene | 40 - 20 | Cosby | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Pigeon Forge | 17 - 0 | Northview Academy | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Sevier County | 34 - 28 | Knoxville Halls | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | Seymour | 7 - 66 | Greeneville | 19:00:007:00 pm | |
| 2021-10-01 19:00:00October 1, 2021 | William Blount | 21 - 28 | West Ridge | 19:00:007:00 pm | |
| 2021-10-08 19:00:00October 8, 2021 | Carter | 24 - 19 | Morristown West | 19:00:007:00 pm | |
| 2021-10-08 19:00:00October 8, 2021 | Cosby | - - W | Oakdale | 19:00:00Canceled | |
| 2021-10-08 19:00:00October 8, 2021 | Gatlinburg-Pittman | W - - | Hampton | 19:00:00Canceled | |
| 2021-10-08 19:00:00October 8, 2021 | Jefferson County | 42 - 7 | Hardin Valley | 19:00:007:00 pm | |
| 2021-10-08 19:00:00October 8, 2021 | Lakeway Christian  | 27 - 42 | TKA | 19:00:007:00 pm | |
| 2021-10-08 19:00:00October 8, 2021 | Morristown East | 42 - 7 | Cocke County | 19:00:007:00 pm | |
| 2021-10-08 19:00:00October 8, 2021 | Northview Academy | 14 - 26 |  Grainger | 19:00:007:00 pm | |
| 2021-10-14 19:00:00October 14, 2021 | Northview Academy | 6 - 48 | Gatlinburg-Pittman | 19:00:007:00 pm | |
| 2021-10-14 19:00:00October 14, 2021 | Sevier County | 42 - 0 | Heritage | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | Alcoa | W - - | Union County | 19:00:00Canceled | |
| 2021-10-15 19:00:00October 15, 2021 | Austin-East | 14 - 24 | Pigeon Forge | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | Cocke County | 7 - 76 | West | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | Cosby | 12 - 54 | Unaka | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | Grainger | 14 - 35 | Seymour | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | Hardin Valley | 3 - 61 | Maryville | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | Science Hill | 37 - 0 | Jefferson County | 19:00:007:00 pm | |
| 2021-10-15 19:00:00October 15, 2021 | William Blount | 21 - 48 | Dobyns-Bennett | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Knoxville Webb | 6 - 56 | TKA | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Hardin Valley | 22 - 15 | William Blount | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Cosby | 6 - 57 | Sale Creek | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Alcoa | 42 - 0 | Tyner Academy | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Campbell County | 14 - 23 | Sevier County | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Carter | 42 - 38 | South-Doyle | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Cosby | - | Sale Creek | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Gatlinburg-Pittman | 56 - 18 | Scott | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Hardin Valley | - | William Blount | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Heritage | 14 - 20 | Lenoir City | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Jefferson County | 55 - 14 | Morristown West | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Maryville | 35 - 7 | West | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | Pigeon Forge | 35 - 0 | Happy Valley | 19:00:007:00 pm | |
| 2021-10-22 19:00:00October 22, 2021 | South Greene | 28 - 21 | Seymour | 19:00:007:00 pm | |
| 2021-10-28 19:00:00October 28, 2021 | Cosby | 28 - 6 | Hancock County | 19:00:007:00 pm | |
| 2021-10-28 19:00:00October 28, 2021 | Gatlinburg-Pittman | 14 - 17 | Pigeon Forge | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Fulton | 24 - 8 | Carter | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | TKA | 41 - 7 | Notre Dame | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Knoxville Halls | 58 - 0 | Heritage | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Maryville | 42 - 14 | Bradley Central | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Northview Academy | 36 - 28 | Union County | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Sevier County | 48 - 3 | Cocke County | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Seymour | 8 - 56 | Elizabethton | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | South-Doyle | 38 - 7 | Gibbs | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | West Ridge | 35 - 12 | Jefferson County | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | William Blount | 22 - 31 | Morristown East | 19:00:007:00 pm | |
| 2021-10-29 19:00:00October 29, 2021 | Alcoa | 64 - 0 | Austin-East | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Unicoi County | 25 - 16 | Austin-East | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Pigeon Forge | 21 - 20 | West Greene | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Chuckey-Doak | 35 - 40 | Gatlinburg-Pittman | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Alcoa | W - Forfeit | Johnson County | 19:00:00Canceled | |
| 2021-11-05 19:00:00November 5, 2021 | Greeneville | 49 - 14 | South-Doyle | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Anderson County | 39 - 21 | Seymour | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | David Crockett | 24 - 14 | Sevier County | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Bradley Central | 24 - 21 | Jefferson County | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | Maryville | 41 - 14 | Dobyns-Bennett | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | TKA | 55 - 36 | Franklin Grace | 19:00:007:00 pm | |
| 2021-11-05 19:00:00November 5, 2021 | TKA | 0 - 49 | USJ | 19:00:007:00 pm | |
| 2021-11-05 19:00:43November 5, 2021 | Elizabethton | 47 - 14 | Carter | 19:00:437:00 pm | |
| 2021-11-12 19:00:00November 12, 2021 | Gatlinburg-Pittman | 0 - 63 | Alcoa | 19:00:007:00 pm | |
| 2021-11-12 19:00:00November 12, 2021 | Unicoi County | 0 - 24 | Pigeon Forge | 19:00:007:00 pm | |
| 2021-11-12 19:00:00November 12, 2021 | Maryville | 49 - 0 | West Ridge | 19:00:007:00 pm | |
| 2021-11-19 19:00:00November 19, 2021 | Pigeon Forge | 0 - 52 | Alcoa | 19:00:007:00 pm | |
| 2021-11-19 19:00:00November 19, 2021 | Maryville | 28 - 21 | Farragut | 19:00:007:00 pm | |
| 2021-11-26 19:00:19November 26, 2021 | Alcoa | 42 - 12 | Giles County | 19:00:197:00 pm | |
| 2021-11-26 19:00:55November 26, 2021 | Maryville | 14 - 24 | Oakland | 19:00:557:00 pm | |
| 2021-12-03 11:00:19December 3, 2021 | Alcoa | 45 - 14 | East Nashville | 11:00:1911:00 am | |
