| Date | Home | Results | Away | Time | Venue |
|---|---|---|---|---|---|
Maryville  | 45 - 7 |  Heritage | Shields Stadium | ||
Sevier County  | 7 - 6 |  Jefferson County | Burchfield Stadium | ||
Knoxville Webb  | 46 - 21 |  Carter | David Meske Stadium | ||
Cocke County  | 33 - 9 | Cherokee | Cocke County High School Stadium | ||
Seymour  | 14 - 45 |  Gatlinburg-Pittman | Seymour High School Football Stadium | ||
Lakeway Christian  | 26 - 24 | Grace Christian | Lakeway Christian Football Stadium | ||
Pigeon Forge  | 16 - 20 | Hampton | Jim Whaley Field | ||
| Clinton | 48 - 0 |  William Blount | Clinton High School Football Field | ||
| Rhea County | 21 - 38 |  Alcoa | Eagles Football Stadium | ||
Cosby  | 49 - 20 | Sunbright | Cosby High School Stadium | ||
| Cumberland Gap | 32 - 42 |  Grainger | Cumberland Gap High School Football Stadium | ||
| Unicoi County | 42 - 20 |  Northview Academy | Gentry Football Stadium | ||
South-Doyle  | 20 - 46 | Oak Ridge | Billy K. Nicely Stadium | ||
TKA  | 0 - 16 |  CAK | The King's Academy Football Stadium | ||
Morristown East  | 7 - 24 |  Morristown West | Burke-Toney Stadium | ||
| Gatlinburg-Pittman | 17 - 52 | Alcoa | Hammonds Stadium | ||
| Powell | 13 - 38 | Maryville | PHS Football Stadium | ||
| Carter | 14 - 20 | Sevier County | Hornets Field | ||
| Jefferson County | 45 - 3 | Cocke County | Leroy Shannon Field | ||
| Heritage | 28 - 46 | Campbell County | Jack Renfro Stadium | ||
| Lakeway Christian | 48 - 7 | Midway | Lakeway Christian Football Stadium | ||
| Morristown East | 34 - 28 | Knoxville Halls | Burke-Toney Stadium | ||
| Hardin Valley | 13 - 27 | Morristown West | Hardin Valley Academy Stadium | ||
| Northview Academy | 44 - 13 | West Greene | Cougar Football Field | ||
| Cherokee | 28 - 42 | Seymour | Mike Sivert Field | ||
| Grace Christian | 28 - 34 | South-Doyle | Grace Christian Academy Football Field | ||
| William Blount | 14 - 42 | Karns | Mike White Field | ||
| Cosby | 0 - 42 | Unicoi County | Cosby High School Stadium | ||
| Grainger | 0 - 35 | Greeneville | Grainger High School Football Field | ||
| Sullivan East | 35 - 26 | Pigeon Forge | Alumni Football Stadium | ||
| TKA | 34 - 24 | Meigs County | The King's Academy Football Stadium | ||
| West Georgia | 38 - 7 |  Carson-Newman | University Stadium | ||
Tusculum  | 70 - 13 | St. Augustine’s | Pioneer Field | ||
| Alcoa | 61 - 6 | Northview Academy | Goddard Field | ||
| North Greene | 12 - 50 | Lakeway Christian | The Tundra | ||
| Pigeon Forge | 54 - 0 |  Union County | Jim Whaley Field | ||
| Seymour | 41 - 20 | Volunteer | Householder Field | ||
Tennessee  | 59 - 10 | Ball State | Neyland Stadium | ||
| Carter | 26 - 42 | Gibbs | Hornets Field | ||
| Heritage | 45 - 21 | Cocke County | Jack Renfro Stadium | ||
| Gatlinburg-Pittman | 38 - 6 |  Austin-East | Hammonds Stadium | ||
| William Blount | 6 - 45 | Jefferson County | Mike White Field | ||
| Maryville | 41 - 28 |  Farragut | Shields Stadium | ||
| Dobyns-Bennett | 42 - 14 | Morristown East | J. Fred Johnson Stadium | ||
| Morristown West | 31 - 9 | David Crockett | Burke-Toney Stadium | ||
| Sevier County | 21 - 14 | Knoxville Central | Burchfield Stadium | ||
| Jellico | 21 - 48 | Cosby | Jellico High School Football Field | ||
| Grainger | 28 - 24 | Sullivan East | Grainger High School Football Field | ||
| South-Doyle | 42 - 30 |  Scott | Billy K. Nicely Stadium | ||
| TKA | 12 - 19 | Howard School | The King's Academy Football Stadium | ||
Maryville College  | 24 - 31 | Berry College | Thornton Stadium | ||
| Walker Valley | 3 - 14 | Carter | Walker Valley High School Stadium | ||
| Maryville | 14 - 27 | Alcoa | Shields Stadium | ||
| Seymour | 13 - 16 | Cocke County | Seymour High School Football Stadium | ||
| Gatlinburg-Pittman | 35 - 28 |  Loudon | Hammonds Stadium | ||
| William Blount | 20 - 38 | Heritage | Mike White Field | ||
| Jefferson County | 28 - 21 | Knoxville Halls | Leroy Shannon Field | ||
| Silverdale Academy | 47 - 19 | Lakeway Christian | Silverdale Academy Football Stadium | ||
| Morristown West | 21 - 28 | Greeneville | Burke-Toney Stadium | ||
| Pigeon Forge | 0 - 19 | Sevier County | Jim Whaley Field | ||
| South-Doyle | 21 - 56 |  Bearden | Billy K. Nicely Stadium | ||
| Grace Christian | 28 - 8 | TKA | Grace Christian Academy Football Field | ||
| Cosby | 27 - 28 | Red Boiling Springs | Cosby High School Stadium | ||
| Grainger | 30 - 56 | Chuckey-Doak | Grainger High School Football Field | ||
| Campbell County | 34 - 33 | Morristown East | Pat Kerr Field | ||
| Northview Academy | 70 - 35 | Claiborne | Cougar Football Field | ||
| Carson-Newman | 27 - 6 | Franklin Pierce | Burke-Tarr Stadium | ||
| Chowan | 21 - 23 | Tusculum | Garrison Stadium | ||
| Pittsburgh | 27 - 34 | Tennessee | Heinz Field | ||
| Centre College | 20 - 10 | Maryville College | Farris Stadium | ||
| Alcoa | 47 - 20 | Pigeon Forge | Goddard Field | ||
| Cocke County | 7 - 57 | Knoxville Halls | Cocke County High School Stadium | ||
| Union County | 0 - 47 | Gatlinburg-Pittman | Union County High School Football Stadium | ||
| Knoxville Central | 32 - 28 | Heritage | Central High School Football Stadium | ||
| Lakeway Christian | 14 - 42 | Gordonsville | Lakeway Christian Football Stadium | ||
| Maryville | 28 - 7 | Bearden | Shields Stadium | ||
| Morristown East | 12 - 35 | Jefferson County | Burke-Toney Stadium | ||
| Daniel Boone | 38 - 7 | Morristown West | Ken Green Field | ||
| Northview Academy | 20 - 26 | Austin-East | Cougar Football Field | ||
| Sevier County | 0 - 49 |  West | Burchfield Stadium | ||
| Anderson County | 35 - 7 | South-Doyle | Anderson County Mavericks Football Stadium | ||
| William Blount | 0 - 35 | Science Hill | Mike White Field | ||
| Carter | 56 - 8 | Scott | Hornets Field | ||
| Elizabethton | 47 - 0 | Grainger | Citizens Bank Stadium | ||
| Sullivan East | 21 - 28 | Seymour | Alumni Football Stadium | ||
| TKA | 0 - 33 | Friendship Christian | The King's Academy Football Stadium | ||
| Carson-Newman | 37 - 40 | Limestone | Burke-Tarr Stadium | ||
| Maryville College | 29 - 34 | Shenandoah University | Thornton Stadium | ||
| Tusculum | 10 - 27 | Wingate | Pioneer Field | ||
| Tennessee | 63 - 6 | Akron | Neyland Stadium | ||
| Alcoa | 26 - 29 | West | Goddard Field | ||
| Carter | 37 - 35 | Karns | Hornets Field | ||
| Morristown West | 48 - 12 | Cocke County | Burke-Toney Stadium | ||
| Gatlinburg-Pittman | 28 - 24 | Coosa Christian (AL) | Hammonds Stadium | ||
| Heritage | 55 - 0 | Seymour | Jack Renfro Stadium | ||
| Lakeway Christian | 21 - 38 | Middle Tennessee Christian | Lakeway Christian Football Stadium | ||
| Science Hill | 14 - 42 | Maryville | Kermit-Tipton Stadium | ||
| Sevier County | 43 - 7 | William Blount | Burchfield Stadium | ||
| Farragut | 58 - 14 | South-Doyle | Eddie Courtney Stadium | ||
| Cosby | 24 - 40 | Cloudland | Cosby High School Stadium | ||
| Union County | 12 - 33 | Grainger | Union County High School Football Stadium | ||
| Oneida | 24 - 21 | Northview Academy | Jim May Stadium | ||
| Scott | 7 - 41 | Pigeon Forge | Scott High School Football Stadium | ||
| Tennessee | 38 - 33 | Florida | Neyland Stadium | ||
| Greensboro College | 17 - 37 | Maryville College | Jamieson Stadium | ||
| Catawba | 17 - 50 | Tusculum | Shuford Stadium | ||
| Lenoir-Rhyne | 34 - 13 | Carson-Newman | Moretz Stadium | ||
| Science Hill | 35 - 21 | Morristown East | Kermit-Tipton Stadium | ||
| Barton | 13 - 14 | Tusculum | Truist Stadium | ||
| Cookeville | 7 - 35 | Alcoa | Tucker Stadium | ||
| Cocke County | 31 - 42 | Knoxville Central | Cocke County High School Stadium | ||
| Carter | 22 - 49 | Anderson County | Hornets Field | ||
| West | 41 - 0 | Heritage | West High School Football Stadium | ||
| Jefferson County | 10 - 34 | Dobyns-Bennett | Leroy Shannon Field | ||
| Monterey | 30 - 21 | Lakeway Christian | Monterey High School Football Stadium | ||
| Morristown West | 30 - 7 | Tennessee High | Burke-Toney Stadium | ||
| Northview Academy | 20 - 21 | Pigeon Forge | Cougar Football Field | ||
| Knoxville Halls | 0 - 7 | Sevier County | Halls High Stadium | ||
| South-Doyle | 29 - 48 |  Fulton | Billy K. Nicely Stadium | ||
| Middle Tennessee Christian | 15 - 12 | TKA | Throneberry Stadium | ||
| West Ridge | 42 - 14 | William Blount | West Ridge High School Football Stadium | ||
| Cosby | 41 - 26 | North Greene | Cosby High School Stadium | ||
| Grainger | 28 - 7 | Volunteer | Grainger High School Football Field | ||
| Cleveland | 28 - 24 | Maryville | Benny Monroe Stadium | ||
| Greeneville | 54 - 0 | Seymour | Burley Stadium | ||
| Carson-Newman | 24 - 14 | Newberry | Burke-Tarr Stadium | ||
| Maryville College | 28 - 42 | Huntingdon College | Thornton Stadium | ||
| TKA | 52 - 22 | Lakeway Christian | The King's Academy Football Stadium | ||
| Morristown West | 7 - 13 | Carter | Burke-Toney Stadium | ||
| Cocke County | 3 - 44 | Morristown East | Cocke County High School Stadium | ||
| Gatlinburg-Pittman | 48 - 40 | Hampton | Hammonds Stadium | ||
| Hardin Valley | 7 - 17 | Jefferson County | Hardin Valley Academy Stadium | ||
| Knoxville Central | 49 - 20 | South-Doyle | Central High School Football Stadium | ||
| Oakdale | 50 - 12 | Cosby | Oakdale High School Football Field | ||
| Grainger | 7 - 20 | Northview Academy | Grainger High School Football Field | ||
| LSU | 13 - 40 | Tennessee | Tiger Stadium | ||
| LaGrange College | 17 - 56 | Maryville College | Callaway Stadium | ||
| Tusculum | 34 - 6 | Carson-Newman | Pioneer Field | ||
| Seymour | 7 - 28 | Grainger | Seymour High School Football Stadium | ||
| Pigeon Forge | 30 - 14 | Austin-East | Jim Whaley Field | ||
| Alcoa | 49 - 0 | Union County | Goddard Field | ||
| West | 64 - 0 | Cocke County | West High School Football Field | ||
| Gatlinburg-Pittman | 50 - 13 | Northview Academy | Hammonds Stadium | ||
| Heritage | 16 - 13 | Sevier County | Jack Renfro Stadium | ||
| Jefferson County | 7 - 21 | Science Hill | Leroy Shannon Field | ||
| Maryville | 42 - 6 | Hardin Valley | Shields Stadium | ||
| Morristown East | 54 - 31 | West Ridge | Burke-Toney Stadium | ||
| Cherokee | 20 - 50 | Morristown West | Mike Sivert Field | ||
| Dobyns-Bennett | 55 - 7 | William Blount | J. Fred Johnson Stadium | ||
| Unaka | 64 - 0 | Cosby | Goddard Field | ||
| Tennessee | 52 - 49 | Alabama | Neyland Stadium | ||
| Southern Virginia University | 7 - 45 | Maryville College | Knight Stadium | ||
| UVA Wise | 9 - 10 | Tusculum | Carl Smith Stadium | ||
| Carson-Newman | 37 - 0 | Erskine | Burke-Tarr Stadium | ||
| South-Doyle | 13 - 47 | Carter | Billy K. Nicely Stadium | ||
| Alcoa | 42 - 20 | Tyner Academy | Goddard Field | ||
Lenoir City  | 38 - 21 | Heritage | Lenoir City High School Football Stadium | ||
| Morristown West | 24 - 28 | Jefferson County | Burke-Toney Stadium | ||
| Lakeway Christian | 7 - 38 | Friendship Christian | Lakeway Christian Football Stadium | ||
| West | 31 - 18 | Maryville | West High School Football Stadium | ||
| Sevier County | 45 - 48 | Campbell County | Burchfield Stadium | ||
| Seymour | 7 - 19 | South Greene | Householder Field | ||
| William Blount | 25 - 42 | Hardin Valley | Mike White Field | ||
| Sale Creek | 53 - 14 | Cosby | Sale Creek High School Football Stadium | ||
| Scott | 20 - 51 | Gatlinburg-Pittman | Scott High School Football Stadium | ||
| Claiborne | 7 - 42 | Grainger | Daniel Huff Tower Stadium | ||
| Greeneville | 42 - 7 | Morristown East | Burley Stadium | ||
| Happy Valley | 19 - 48 | Pigeon Forge | Happy Valley High School Football Stadium | ||
| TKA | 54 - 38 | The Webb School | The King's Academy Football Stadium | ||
| Tennessee | 65 - 24 | UT-Martin | Neyland Stadium | ||
| Mars Hill | 44 - 13 | Carson-Newman | Belk Field | ||
| Maryville College | 61 - 7 | North Carolina Weslyan | Thornton Stadium | ||
| Tusculum | 35 - 9 | Emory & Henry | Pioneer Field | ||
| Elizabethton | 62 - 0 | Seymour | Citizens Bank Stadium | ||
| Austin-East | 0 - 37 | Alcoa | G.H. Lennon Stadium | ||
| Carter | 72 - 54 | Fulton | Hornets Field | ||
| Cocke County | 25 - 20 | Sevier County | Cocke County High School Stadium | ||
| Pigeon Forge | 20 - 21 | Gatlinburg-Pittman | Jim Whaley Field | ||
| Heritage | 20 - 42 | Knoxville Halls | Jack Renfro Stadium | ||
| Jefferson County | 61 - 35 | West Ridge | Leroy Shannon Field | ||
| The Webb School | 45 - 52 | Lakeway Christian | Lagler Field | ||
| Bradley Central | 13 - 48 | Maryville | Bear Stadium | ||
| Morristown East | 62 - 7 | William Blount | Burke-Toney Stadium | ||
| Union County | 6 - 55 | Northview Academy | Union County High School Football Stadium | ||
| Gibbs | 71 - 42 | South-Doyle | Ernest Whited Stadium | ||
| Cosby | 40 - 18 | Hancock County | Cosby High School Stadium | ||
| TKA | 12 - 17 | Notre Dame | The King's Academy Football Stadium | ||
| Tennessee | 44 - 6 | Kentucky | Neyland Stadium | ||
| Emory & Henry | 7 - 21 | Carson-Newman | Fred Selfe Stadium | ||
| Tusculum | 49 - 14 | Erskine | Pioneer Field | ||
| Maryville College | 21 - 24 | Brevard College | Thornton Stadium | ||
| Alcoa | 42 - 0 | Johnson County | Alcoa Football Stadium | ||
| West Greene | 0 - 48 | Pigeon Forge | West Greene Football Stadium | ||
| Gatlinburg-Pittman | 56 - 28 | Unicoi County | Hammonds Stadium | ||
| Maryville | 49 - 0 | Morristown East | Maryville Football Stadium | ||
| Morristown West | 31 - 21 | Sevier County | Morristown West Stadium | ||
| Anderson County | 55 - 6 | Seymour | Anderson County Stadium | ||
| Gibbs | 49 - 14 | Grainger | Gibbs Football Stadium | ||
| Oliver Springs | 35 - 21 | Cosby | Oliver Springs Stadium | ||
| Clarksville Academy | 42 - 43 | Lakeway Christian | Clarksville Academy Stadium | ||
| Trinity Christian | 24 - 20 | TKA | Trinity Christian Football Stadium | ||
| Elizabethton | 49 - 7 | Carter | |||
| Farragut | 17 - 7 | Jefferson County | |||
| Georgia | 27 - 13 | Tennessee | Sanford Stadium | ||
| Mars Hill | 34 - 27 | Tusculum | Belk Field | ||
| Carson-Newman | 38 - 22 | UVA Wise | Burke-Tarr Stadium | ||
| West | 68 - 14 | Morristown West | Class 5A Playoff 2nd Round | ||
| Chuckey-Doak | 34 - 47 | Gatlinburg-Pittman | Class 3A Playoff 2nd Round | ||
| Alcoa | 42 - 20 | Pigeon Forge | Class 3A Playoff 2nd Round | ||
| Maryville | 28 - 10 | Bearden | Class 6A Playoff 2nd Round | ||
| USJ | 48 - 6 | Lakeway Christian | Division II Class A Playoff Quarterfinals | ||
| Tennessee | 66 - 24 | Missouri | Neyland Stadium | ||
| Catawba | 23 - 61 | Carson-Newman | Shuford Stadium | ||
| Belhaven University | 22 - 25 | Maryville College | Belhaven Bowl Stadium | ||
| Lenoir-Rhyne | 34 - 14 | Tusculum | Moretz Stadium | ||
| Alcoa | 56 - 21 | Gatlinburg-Pittman | Class 3A State Quarterfinal | ||
| Maryville | 38 - 14 | Science Hill | Class 6A State Quarterfinal | ||
| South Carolina | 63 - 38 | Tennessee | Williams-Bryce Stadium | ||
| Alcoa | 38 - 13 | Giles County | Class 3A State Semifinal | ||
| Maryville | 15 - 38 | Oakland | Class 6A State Semifinal | ||
| Vanderbilt | 0 - 56 | Tennessee | Vanderbilt Stadium | ||
| East Nashville | 26 - 45 | Alcoa | Class 3A State Championship | ||
| Clemson | 14 - 31 | Tennessee | Capital One Orange Bowl |